Glial cells and inflammation in parkinson's disease: A role in neurodegeneration?
Identifieur interne : 000238 ( France/Analysis ); précédent : 000237; suivant : 000239Glial cells and inflammation in parkinson's disease: A role in neurodegeneration?
Auteurs : Hirsch [France] ; S. Hunot [France] ; P. Damier [France] ; B. Faucheux [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 1998-09.
Abstract
The data reviewed here show that, in Parkinson's disease (PD), some dopaminergic neurons are more vulnerable than others to the pathologic process. The glial cells surrounding dopaminergic neurons may be involved in this selective vulnerability. One subpopulation of glial cells, in particular, may play a neuroprotective role by metabolizing dopamine and scavenging oxygen free radicals that are associated with dopamine metabolism. Another subpopulation of glial cells may be deleterious to dopaminergic neurons. This effect may be mediated by the production of nitric oxide and cytokines, which may in turn account for the oxidative stress observed in the substantia nigra of patients with PD. Finally, this inflammatory reaction may result in the induction of apoptosis.
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DOI: 10.1002/ana.410440717
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ISTEX:144FEF24C3D2A02961759B0C6FA76F29AA3730CELe document en format XML
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Hunot</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 289, Hǒpital de la Salpětrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>INSERM U 289, Hǒpital de la Salpětrière, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Faucheux, B" sort="Faucheux, B" uniqKey="Faucheux B" first="B." last="Faucheux">B. 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The glial cells surrounding dopaminergic neurons may be involved in this selective vulnerability. One subpopulation of glial cells, in particular, may play a neuroprotective role by metabolizing dopamine and scavenging oxygen free radicals that are associated with dopamine metabolism. Another subpopulation of glial cells may be deleterious to dopaminergic neurons. This effect may be mediated by the production of nitric oxide and cytokines, which may in turn account for the oxidative stress observed in the substantia nigra of patients with PD. Finally, this inflammatory reaction may result in the induction of apoptosis.</div></front></TEI><affiliations><list><country><li>France</li></country><settlement><li>Paris</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Hirsch" sort="Hirsch" uniqKey="Hirsch" last="Hirsch">Hirsch</name></noRegion><name sortKey="Damier, P" sort="Damier, P" uniqKey="Damier P" first="P." last="Damier">P. Damier</name><name sortKey="Faucheux, B" sort="Faucheux, B" uniqKey="Faucheux B" first="B." last="Faucheux">B. Faucheux</name><name sortKey="Hunot, S" sort="Hunot, S" uniqKey="Hunot S" first="S." last="Hunot">S. Hunot</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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